Drug: Amantadine

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The Ultimate Manual of Amantadine: Uses, Benefits, and Side Effects


Amantadine is a medication that has been used over the years. Initially, it was intended for use as an antivirus for influenza and later found to be useful in Parkinson’s disease and drug-induced extrapyramidal disorders. It is a flexible medicine utilized widely in medical practice across the globe. In this all-round manual, we will take you through various aspects of Amantadine including its uses, how it functions, potential side effects and important considerations for patients as well as health care providers.


What is Amantadine?


Amantadine is a synthetic antiviral and anti-Parkinsonian drug chemically known as 1-adamantanamine. FDA approved this medicine during the 1960s to help prevent and treat the influence A virus infections. Today it can be used in managing symptoms associated with Parkinson’s disease and drug induced extrapyramidal syndromes.


How Does Amantadine Work?


The mechanism by which Amantadine works is multifaceted. It inhibits replication of influenza A virus by blocking M2 protein which forms a channel involved in virus lifecycle making it an antiviral agent. The effectiveness of Amantadine against Parkinson’s disease among other movement disorders may be due to its increment of dopamine release while blocking its reuptake thereby increasing dopaminergic transmission within the brain.


Uses of Amantadine

  • Influenza A Prevention and Treatment: amantidine can be used for prevention or treatment of respiratory infections caused by influenza A viruses.
  • Parkinson's Disease Management: It helps to manage symptoms such as stiffness, tremors and bradykinesia in Parkinson’s disease.
  • Drug-Induced Extrapyramidal Symptoms: Amantadine can alleviate unwanted movements associated with some psychiatric medication side effects.

Potential Side Effects of Amantadine


Sometimes, amantadine may cause side effects although it is beneficial for many patients. Common side effects include dizziness, insomnia, nausea and xerostomia. In some cases, more severe ones like hallucinations are less common but they might be experienced as well as depression or orthostatic hypotension. Therefore it is important to talk to a doctor before taking this medicine so that you know if you can use it.


Important Considerations and Interactions


In addition, one should be cautious when using amantadine if they have previously suffered from epilepsy, renal dysfunction or liver failure. Additionally the medicine interacts with other drugs like anticholinergic drugs, live vaccines and other certain antiviral drugs leading to undesirable outcomes in humans. Prior to beginning the treatment with Amantadine always notify your physician about your current medications including any that you were taking earlier on.




Apart from offering substantial advantages in the management of flu A infection; Parkinson’s disease and drug-induced extrapyramidal reactions (EPS), amantidine makes an excellent multipurpose drug. However it also has potential side effects and interactions just like any other drug in existence which must be properly considered. In case you are looking forward towards benefiting from Amantidine, consider a consultation with a healthcare provider to ensure that it is the right treatment for you.

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